WP7 - Use Cases
The objective of WP7 is supporting the experimentation of various components, organizing the collection of requirements, identifying specific profiles for the use of
the solutions produced by the project, and offering to a variety of end users access to the results. Three use-cases are being planned; in the first study, we involve
biology researchers at work in their laboratories; in the second study, we involve biologists in strong contacts with clinicians who use results of clinical trials which
involve large sets of patients; the third study focuses on how to extract data from large organizations while protecting data security, privacy, provenance and trust.
TASK 7.1 SUPPORT TO BIOINFORMATICS RESEARCH
This use case focuses on the support of the needs of a bioinformatics researcher, who is interested in tools for mining and information discovery within genomic
repositories that are produced using the results of the project. Specifically, this task focuses on the discovery of genetic aberrations within genomic data (e.g.,
translocations, gene fusions, genetic mutations) and their impact in the pathogenesis. We will provide requirements to the other WPs and will be responsible for the
application of their developed tools, models and strategies to RNA and Whole Exome Sequence data provided by associated partners IRCC and CeRMS.
TASK 7.2 SUPPORT TO BIOMEDICAL RESEARCH
A clinical study, performed by the associate partner IEO, will bridge the gap from current medical practice to personalized medicine, immediately translating to the
clinic the research discoveries. Two different setting of patients will be included in the clinical task: patients with a first diagnosis of breast cancer included in a
clinical study in which role of obesity in breast cancer development and progression is the primary endpoint; and patients with severe breast cancer, observed either
progressing to or after standard adjuvant chemotherapy or endocrine therapy.
TASK 7.3 ANONYMIZED RELEASE OF DATA
The goal of this use case is to study the application of modern anonymization techniques over the collections of data that are available in the premises of the hospitals
and local health agencies (ASL) that participate to the project; the specific data collections to be used will be defined in the course of the project. The use case will
consider anonymizations where the usage of the data is either known a priori or unknown; knowledge of the usage profile helps producing anonymized data with
greater utility and/or better privacy guarantees.
the solutions produced by the project, and offering to a variety of end users access to the results. Three use-cases are being planned; in the first study, we involve
biology researchers at work in their laboratories; in the second study, we involve biologists in strong contacts with clinicians who use results of clinical trials which
involve large sets of patients; the third study focuses on how to extract data from large organizations while protecting data security, privacy, provenance and trust.
TASK 7.1 SUPPORT TO BIOINFORMATICS RESEARCH
This use case focuses on the support of the needs of a bioinformatics researcher, who is interested in tools for mining and information discovery within genomic
repositories that are produced using the results of the project. Specifically, this task focuses on the discovery of genetic aberrations within genomic data (e.g.,
translocations, gene fusions, genetic mutations) and their impact in the pathogenesis. We will provide requirements to the other WPs and will be responsible for the
application of their developed tools, models and strategies to RNA and Whole Exome Sequence data provided by associated partners IRCC and CeRMS.
TASK 7.2 SUPPORT TO BIOMEDICAL RESEARCH
A clinical study, performed by the associate partner IEO, will bridge the gap from current medical practice to personalized medicine, immediately translating to the
clinic the research discoveries. Two different setting of patients will be included in the clinical task: patients with a first diagnosis of breast cancer included in a
clinical study in which role of obesity in breast cancer development and progression is the primary endpoint; and patients with severe breast cancer, observed either
progressing to or after standard adjuvant chemotherapy or endocrine therapy.
TASK 7.3 ANONYMIZED RELEASE OF DATA
The goal of this use case is to study the application of modern anonymization techniques over the collections of data that are available in the premises of the hospitals
and local health agencies (ASL) that participate to the project; the specific data collections to be used will be defined in the course of the project. The use case will
consider anonymizations where the usage of the data is either known a priori or unknown; knowledge of the usage profile helps producing anonymized data with
greater utility and/or better privacy guarantees.